CHICAGO — After 99 pitches over six innings, Jose Quintana gave the Chicago White Sox a chance to win.

Then Avisail Garcia gave him the rest of the afternoon off.

Garcia's two-run home run in the sixth inning broke a tie and lifted the White Sox to a 5-2 victory Wednesday, completing a series sweep of the reeling Kansas City Royals, who finished their trip 0-7.

"I wanted to stay in the game and go back in the seventh inning, but" Manager Rick Renteria "said, 'If we take the lead, you stay. If we're tied, you go back,' " Quintana said. 

Quintana (1-4) got the run support he needed after receiving only four runs in his first four starts combined. The left-hander had a season-high 10 strikeouts. He allowed five hits and two runs — one earned — and walked two.

Renteria dispatched relievers Dan Jennings, Tommy Kahnle, Nate Jones and David Robertson for three scoreless innings, with Robertson converting his fifth save in five tries.

"They've been the epitome of a solid bullpen," said Renteria, who knocked on a wooden table twice when talking about the unit, which has combined for a 1.96 ERA, second in the majors.

Garcia's two-run homer, his fourth of the season, went to deep center field to give Chicago a 4-2 lead. Leury Garcia added a solo home run in the seventh inning for the White Sox, who earned their fourth straight win. Chicago's Jose Abreu and Todd Frazier had consecutive two-out RBI doubles in the first inning to open the scoring.

Jorge Bonifacio scored Alcides Escobar on an RBI single in the fifth inning, and Escobar's groundout scored Alex Gordon to tie it at 2 in the top of the sixth.

Right-hander Nathan Karns (0-2) took the loss, allowing four runs in six innings for the Royals, who stranded 11 runners.

"We hit some balls right on the nose, we just couldn't find holes with them," Royals Manager Ned Yost said. "I'm encouraged by what I saw."

The teams will meet again for a four-game series starting Monday in Kansas City, part of a 10-game home stand for the Royals.